Current Issue : January - March Volume : 2020 Issue Number : 1 Articles : 5 Articles
This study aimed to develop a carbamazepine (CBZ) sustained release formulation suitable\nfor pediatric use with a lower risk of precipitation. The CBZ was first prepared as sustained\nrelease microparticles, and then the microparticles were embedded in alginate beads, and finally, the\nbeads were suspended in a gel vehicle. The microparticles were prepared by a solvent evaporation\nmethod utilizing ethyl cellulose as a sustained release polymer and were evaluated for particle size,\nencapsulation efficiency, and release profile. The beads were fabricated by the dropwise addition of\nsodium alginate in calcium chloride solution and characterized for size, shape, and release properties.\nThe gel was prepared using iota carrageenan as the gelling agent and evaluated for appearance,\nsyneresis, drug content uniformity, rheology, release profile, and stability. The microparticles exhibited\na particle size of���������.....
Local administration of vaginal probiotics, especially lactobacilli, has been recently\nproposed as an effective prevention strategy against candidosis recurrences, which affect 40-50% of\nwomen. In this context, the aim of the present work was the development of a mucoadhesive in situ\ngelling formulation for the vaginal administration of Lactobacillus gasseri. Mixtures of poloxamer 407\n(P407) and methylcellulose (MC), two thermosensitive polymers, were prepared and subjected to\nrheological analyses for the assessment of their sol/gel transition temperature. The association of\nP407 (15% w/w) with MC (1.5% w/w) produced an increase in gelation extent at 37 DegreeC even after\ndilution in simulated vaginal fluid (SVF). The presence of 0.5% w/w pectin (PEC) produced a\nreduction of vehicle pH and viscosity at 25 DegreeC that is the vehicle resistance to flow during\nadministration. The presence of a low concentration of xyloglucan (XYL) (0.25% w/w) increases the\nmucoadhesive properties and the capability to gelify at 37 DegreeC of the formulation after dilution with\nSVF. A three-component (P407/MC/PEC; 3cM) and a four-component (P407/MC/PEC/XYL; 4cM)\nmixture were selected as promising candidates for the delivery of L. gasseri to the vaginal cavity.\nThey were able to preserve L. gasseri viability and were cytocompatible towards the HeLa cell line....
The purpose of this work was to develop felodipine-loaded ethosomes to advance its therapeutic efficacy through transdermal delivery. Ethosomes (ES) were fabricated via a 31.21 mixed full factorial design, the factors considered were; phospholipid amount (200 mg and 300 mg), Felodipine amount (10 mg and 20 mg) and ethanol percentage (10% and 15 % v/v). All ethosomes were formulated with thin-film hydration method and characterized for their entrapment efficiency (EE). The optimized ethosomal formula (F-1) consisted of phospholipid (200 mg) and ethanol percentage (10%) and was subjected to morphological examination and in-vitro release study. Spherical vesicles with uniform particle size were displayed from the transmission electron microscopy. Also F-1 showed a superior release profile when compared to felodipine suspension. Consequently, ethosomes could be promising for an improved transdermal delivery of felodipine....
Solid core drug delivery systems (SCDDS) were prepared for the oral delivery of biomolecules\nusing mesoporous silica as core, bovine haemoglobin (bHb) as model drug and supercritical fluid (SCF)\nprocessing as encapsulation technique. The use of organic solvents or harsh processing conditions\nin the development of drug delivery systems for biomolecules can be detrimental for the structural\nintegrity of the molecule. Hence, the coating on protein-immobilised particles was performed via\nsupercritical carbon dioxide (scCO2) processing at a temperature lower than the melting point of\nmyristic acid (MA) to avoid any thermal degradation of bHb. The SCDDS were prepared by bHb\nimmobilisation on mesoporous silica followed by myristic acid (MA) coating at 43 DegreeC and 100 bar in\nscCO2. bHb-immobilised silica particles were also coated via solvent evaporation (SE) to compare the\nprotein release with scCO2 processed formulations. In both cases, MA coating provided required\nenteric protection and restricted the bHb release for the first two hours in simulated gastric fluid\n(SGF). The protein release was immediate upon the change of media to simulated intestinal fluid\n(SIF), reaching 70% within three hours. The release from SCF processed samples was slower than SE\nformulations, indicating superior surface coverage ofMAon particles in comparison to the SE method.\nMost importantly, the protein conformation remained unchanged after the release from SCDDS as\nconfirmed by circular dichroism. This study clearly demonstrates that the approach involving protein\nimmobilisation on silica and scCO2 assisted melt-coating method can protect biomolecules from\ngastric environment and provide the required release of a biologic in intestine without any untoward\neffects on protein conformation during processing or after release....
Over the past few decades, the amorphous solid dispersions (ASDs) technique has emerged\nas a promising strategy to enhance the in vitro/in vivo characteristic of hydrophobic drugs. The low\naqueous solubility and poor bioavailability of atorvastatin calcium (ATO), a lipid-lowering drug,\npresent challenges for effective drug delivery. The objective of this work was to improve the\naqueous solubility, in vitro dissolution, and oral absorption of ATO with amorphous solid dispersion\ntechnique prepared by spray-drying method. The optimized ternary formulation comprising of\nATO; hydroxypropyl methylcellulose (HPMC), as a hydrophilic polymer; and sodium lauryl sulfate\n(SLS), as a surfactant, at a weight ratio of 1/1/0.1, showed significant improvement in aqueous\nsolubility by�����....
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